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Sequencing-based assays (Page 68)
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GSE114034: Characterization of Lgr6+ Cells as an Enriched Population of Hair Cell Progenitors Compared to Lgr5+ Cells for Hair Cell Generation in the Neonatal Mouse Cochlea
Our previous studies showed that Lgr6+ cells are a subpopulation of Lgr5+ progenitor cells and that ...
GSE140438: Mice lung gene expression profiles in response to Mycobacterium abscessus
Mice were challneged with Mycobacterium abscessuscell wall particles intra- tracheally or saline. Lu...
GSE116541: Whole genome characterization of in vitro generated mouse colonic monolayers
We report whole genome data for in vitro mouse monolayers with different culture time/transepithelia...
GSE113036: Pericyte-to-neuron reprogramming via unfolding of a neural stem cell-like program
Ectopic expression of defined transcription factors can force direct cell fate conversion from one l...
GSE116627: High-throughput sequencing reveals induction of drug metabolism in various cholestatic livers
Cholestasis is a multifactorial disorder that compromises liver function. We wanted to examine Phase...
GSE117911: Transcriptional profiling of human intestinal organoids following human norovirus infection
Transcriptional profiling of human intestinal organoids following human norovirus infection. SOURCE:...
GSE115153: Biological effect of chronic mistranslation in mammalian cells
Analysis of HEK293 cells lines expressing mutant ribosomal protein RPS2 (human A226Y). RPS2 A226Y m...
GSE117040: Transcriptional Profiling Identifies Novel Regulators of Macrophage Polarization [RNA-Seq]
Identification of novel differentially expressed genes in human M1 and M2 macrophages using RNA-Seq ...
GSE119060: A fully automated high throughput-workflow for human neural organoids
Recent advances in stem cell technology have led to the development of three-dimensional (3D) cultur...
GSE104769: RNA sequencing of murine Nup98-Phf23-driven pro-B1 ALL
B-1 and B-2 lymphocytes are derived from distinct developmental pathways, and represent layered arms...
GSE114546: Role of a-DR3 on group 3 innate lymphoid cells
In order to examine the role of a-DR3 on group 3 innate lymphoid cells, we treated Rag1-/-Rorcgfp/+...
GSE122919: Lin28 expression affect embryonic lung development
Lin28A and its paralog Lin28B are RNA binding proteins that regulate gene expression by inhibition o...
GSE124217: Human Bacille Calmette-Gurin vaccination elicits trained immunity via the hematopoietic progenitor compartment [PBMC]
Induction of trained immunity by human Bacille-Calmette-Gurin (BCG) vaccination is implicated in the...
GSE115181: Gene expression analysis of wild type and Lats1/2-mutated uveal melanoma
Lats1/2 kinases are the core Hippo pathway kinases. In this study, we use RNAseq to analyze the gene...
GSE116530: Differentiation of transplanted haematopoietic stem cells tracked by single-cell transcriptomic analysis
Transcriptome analysis of hematopoietic cells under homeostasis and regeneration at single cell reso...
GSE114573: Comparison of transcriptome responses to isoxaflutole, quizalofop-p-ethyl and mesotrione in the HepaRG cell line
We provide here the alterations in gene expression profiles of HepaRG cells, a validated model for c...
GSE135914: Sirt6 Oncogene Mediates PI3K/Akt Signaling Activation in Diffuse Large B-Cell Lymphoma
Purpose:Sirtuin 6 (Sirt6) is a highly conserved ADP-ribosylase and NAD+ dependent deacylase, involve...
GSE119153: Targeting the perivascular niche sensitizes disseminated tumour cells to chemotherapy
The presence of disseminated tumour cells (DTCs) in bone marrow predicts poorer metastasis-free surv...
GSE114272: The role of Clk3 in the development of heart hypertrophy
We used RNA-seq technology to characterise the extent of transcriptional response to transverse aort...
GSE118944: RNA-Seq of CD34+ Bone Marrow Progenitors from Healthy Donors
To evaluate the transcriptome and splicing repertoire of bulk CD34+ sorted bone marrow progenitors w...
GSE119013: Effect for target mRNA degradation by methylated microRNAs
To confirme the function of methylated micro RNAs (miR-17 and let-7a), we transfected methylated or ...
GSE115186: RNAseq of CD31-/CD45- pneumocytes after 4 weeks of KRasG12V activation by tamoxifen and 2 weeks of chase
We report the RNAseq data obtained from 50.000-100.000 CD31-/CD45- pneumocytes isolated by FACS from...
GSE119049: Toxicity of LCDD monoclonal Ig free light chains on renal glomeruli
We analyzed the transcriptome (RNA-seq) of glomeruli in a mouse model of light chain deposition dise...
GSE119145: Effect of TGF-beta treatment on circRNAs biogenesis
circRNAs profile were examined upon TGF-beta treatment in A549 cells SOURCE: yu xiang (yu.xiang@uth....
GSE114927: RNAseq analysis of whole islets from pre-weaning wild type and Akita mice
This study aims to determine the effects of proinsulin misfolding/ER stress on -cell dynamics and fu...
GSE115188: The influence of adolescent nicotine exposure on ethanol intake brain gene expression
Background: Nicotine and alcohol are often co-abused. Adolescence is a vulnerable period for the ini...
GSE104850: Interrogating the functions of PRDM9 domains in meiosis
Homologous recombination is required for proper segregation of homologous chromosomes during meiosis...
GSE121188: Next Generation Sequencing Facilitates Quantitative Analysis of Wild Type and SMAD4 Y95 Mutation Transcriptomes
Purpose: Next-generation sequencing (NGS) has revolutionized systems-based analysis of Y95 phosphory...
GSE115190: RNA-seq analysis of whole liver derived from endothelial specific TAK1 conditional knockout mice.
In this study we show that TGF-activated kinase 1 (TAK1), is crucial for ensuring EC survival on TNF...
GSE114913: Mouse duodenal enteroendocrine transcriptome
Using genetically modifed mice to express fluorescent reporter in proglucagon expressing cells (GluV...
GSE134557: Endothelial TGF signaling drives vascular inflammation and atherosclerosis [scRNA-Seq]
Endothelial TGF signaling is one of the primary drivers of atherosclerosis-associated vascular infla...
GSE116519: Gene expression in WT and Thpok-deficient LCMV-specific memory T cells
Gene expression of memory CD4+ and CD8+ T cells determined by RNAseq 30 days after LCMV Armstrong in...
GSE114593: Analysis of functions of Rlim during reproduction in male mice
The transcriptomes of mouse testes isolated from 8 weeks old male littermates carrying germline Rlim...
GSE116126: A role for ZNF598 in post-transcriptional gene regulation
Transcriptomic changes in U2OS cells upon depletion of the RNA-binding protein ZNF598 were analyzed ...
GSE106882: Neonatally imprinted mesenteric lymph node stromal cell subsets induce tolerogenic dendritic cells [resDCs]
Gut-draining mesenteric lymph nodes (mLNs) play a key role in peripheral tolerance towards food and ...
GSE116009: Hippocampal changes in the transcriptome of alpha-synuclein overexpressing mice housed in standard or chronic mild stress environment
Using a mouse model overexpressing human SNCA and profiling the striatal transcriptome, we assessed ...
GSE118757: PRC2 proteins EZH1 and EZH2 regulate postnatal hepatic maturation [RNA-Seq]
The inability to derive fully functional cell types, such as hepatocytes, from stem cells may emanat...
GSE134581: Comparison of transcriptional changes in CD103 positive dendritic cells in mice lacking Il33 expression in DCs relative to control mice
IL33 is an alarmin protein that is known to be released by epithelial cells as a response to damage....
GSE111864: Small RNAs gained during epididymal transit of sperm are essential for embryonic development in mice
The small RNA payload of mammalian sperm undergoes dramatic remodeling during development, as severa...
GSE107642: Next Generation Sequencing Facilities Quantitative Analysis of Wild type iNKT cells at stage2 and stage3 transcriptomes
Purpose:Next Generation Sequencing applying for compare the iNKT cells at stage2 and stage3 distict ...
GSE141708: mRNA profiles of human Dedifferentiated Adipose Cells and Adipose-derived stem cells in young donors
Dedifferentiated Fat Cells (DAs) and Adipose-derived stem cells (ADSCs) are two main stem cells deri...
GSE108896: Exploring the transcriptome of resident spinal microglia after collagen antibody-induced arthritis
Microglia have emerged as crucial players in the maintenance of mechanical hypersensitivity in model...
GSE119710: Female-biased embryonic death from genomic instability-induced inflammation
To identify sex-based differences in gene pathways affected by endgoenous genomic instaiblity result...
GSE130069: mRNA profiling of Pontin WT and RA under glucose starvation
To determine which genes are affected by methylated Pontin, we performed RNA-sequencing (RNA-seq) in...
GSE113049: Single Cell RNA Sequencing Identifies TGF as a Key Regenerative Cue following LPS-induced Lung Injury
Many lung diseases result from a failure of efficient regeneration of damaged alveolar epithelial ce...
GSE138783: RNA-Seq to evaluate detaining intron splicing upon O-GlcNAc perturbation
We report the effect of splicing upon O-GlcNAc perturbation with OGT inhibitor or OGA inhibitor. We ...
GSE121284: Molecular and functional heterogeneity of IL-10-producing CD4+ T cells [Mouse Bulk-seq]
IL-10 is a prototypical anti-inflammatory cytokine, which is fundamental to the maintenance of immun...
GSE121525: Effect of high-fat diet on hepatic gene expression in SM/J mice
We identified 4,356 genes with expression differences associated with a high-fat diet, with 184 gene...
GSE114383: Expression analysis of PC3 cells treated with scramble AON or AON directed against MBNL1
We transfected PC3 cells with 100nM of a scrambled antisense oligonucleotide (AON) and an AON direct...
GSE119103: Corrupted coordination of epigenetic modifications leads to diverging chromatin states and transcriptional heterogeneity in chronic lymphocytic leukemia
Cancer evolution is fueled by genetic and epigenetic diversity, and intra-tumoral heterogeneity in D...
GSE119423: The SUMO Pathway as a Therapeutic Option in Pancreatic Cancer
Pancreatic ductal adenocarcinoma (PDAC) still carries a dismal prognosis with overall five-year surv...
GSE114313: A distinct lineage of origin reveals heterogeneity of plasmacytoid dendritic cells II (scRNAseq)
Plasmacytoid dendritic cells (pDCs) are an immune subset devoted to the production of high amounts o...
GSE132047: Meningeal gd T cells regulate anxiety like behaviors via Il17a signaling on Neurons
By characterizing the meningeal compartment of naive mice, here we explored a unique population of t...
GSE118973: Sensory Food Perception Rapidly Primes Postprandial ER-Homeostasis through Melanorcortin-Dependent Control of Liver mTOR Activation
Adaptation of liver to the postprandial state requires coordinate regulation of protein synthesis an...
GSE114579: Trim27 confers myeloid hematopoiesis competitiveness by upregulating myeloid master genes
RNAseq were performed to analyze the transcriptomic differences between Trim27-overexpressing MP and...
GSE119438: Effect of AMI-5 on mouse pancreas differentiation
Mouse embryonic pancreata at 14.5 dpc were cultured for two day in air to liquide interface cultures...
GSE114314: A distinct lineage of origin reveals heterogeneity of plasmacytoid dendritic cells III
Plasmacytoid dendritic cells (pDCs) are an immune subset devoted to the production of high amounts o...
GSE119408: AD-BXD [Ntg dataset 2]
Cg.5XFAD females (MMRRC Stock No #34848-JAX) were bred to males from BXD strains. The resulting F1 p...
GSE119749: Selective expansion of myeloid and NK cells in humanized mice yields human-like vaccine responses (Experiment 1: RNA-seq)
By taking advantage of the highly immunogenic live-attenuated yellow fever virus vaccine YFV-17D, we...
GSE104914: Chemotherapeutic remodeling of the gut microbiome [mouse tissue]
The gut microbiome is a dynamic, malleable microbial community that can provoke phenotypic changes i...
GSE128102: Stage-specific regulation of the WNT/-catenin pathway enhances differentiation of hESCs into hepatocytes
Background & Aims; Hepatocytes differentiated from human embryonic stem cells (hESCs) have the poten...
GSE130401: The hippo pathway effector protein YAP modulated resistance to trametinib neuroblastomas with hyperactivated RAS pathway signalling
We sequenced seven neuroblastoma cell lines, including the parental NLF neuroblastoma cell line and ...
GSE106901: RNA sequencing of sorted cells from mouse PDAC
Pancreatic ductal adenocarcinoma (PDAC) is characterized by the presence of abundant desmoplatic str...
GSE116649: Megadomains and superloops form dynamically during X-chromosome inactivation but are dispensable for silencing and escape
The mammalian inactive X-chromosome (Xi) is structurally distinct from all other chromosomes and ser...
GSE117043: Peptides encoded by 5 untranslated regions mediate pain sensitization
Nociceptors are neurons responsible for the detection of pain producing stimuli. Persistent changes ...
GSE137425: mRNA expression changes in CCM3-deficient endothelial cells
Loss-of-function variants in CCM3/PDCD10 predispose to cerebral cavernous malformations (CCMs) that ...
GSE117288: NuRD-interacting protein ZFP296 regulates genome-wide NuRD localization and differentiation of mouse embryonic stem cells (RNA-seq)
The Nucleosome Remodeling and Deacetylase (NuRD) complex plays an important role in gene expression ...
GSE104842: Bone marrow-derived progenitors become decidual cells and are essential for implantation and pregnancy maintenance
The pregnant decidua is infiltrated by many immune cells which are thought to originate in the bone ...
GSE115070: Studying the genetic heterogeneity in mouse dopamine neurons
Midbrain dopamine neurons project to numerous targets throughout the brain to modulate various behav...
GSE110236: IFNb/LPS activates convergence of inflammatory gene expression patterns between adipocytes and myeloid cells.
We examined the transciptomic changes to primary adipocytes resulting from exposure to IFNb and/or L...
GSE117397: Single cell RNA sequencing reveals microglia-like cells in cerebrospinal fluid during virologically suppressed HIV
Using single cell RNA sequencing (scRNA-seq) on cerebrospinal fluid (CSF) and blood from adults with...
GSE130966: Plasmacytoid dendritic cells develop from Ly6D+ lymphoid progenitors distinct from the myeloid lineage
We provide a comprehensive single cell mRNA-seq analyses of mouse bone marrow progenitors revealing ...
GSE140888: The role of ATG16L1 in the intestinal epithelium
The ATG16L1-deficient intestinal organoids display increased IFN-I signature. SOURCE: Yu Matsuzawa (...
GSE115355: Molecular basis of mitomycin C enhanced corneal sensory nerve repair
We performed RNASeq and confocal imaging analysis to characterize the gene expression changes in the...
GSE116015: Organoid-induced differentiation of conventional T cells from human pluripotent stem cells
Generation of T cells from pluripotent stem cells (PSC) has the potential to transform adoptive immu...
GSE127739: Next Generation Sequencing Analysis of the Transcriptomes of Wild Type and ALKBH5-/- Peritoneal Macrophages
By performing RNA sequencing (RNA-seq) analysis on the peritoneal macrophages that derived from ALKB...
GSE113422: ALYREF links 3'processing and nuclear export of histone mRNAs
To examine whether ALYREF can facilitate the 3'processing of RD histone mRNA,we isolated and sequenc...
GSE105035: Dimethyl fumarate increases fetal hemoglobin, provides heme detoxification, and corrects anemia in sickle cell disease
Sickle cell disease (SCD) results from a point mutation in the -globin gene forming hemoglobin S (Hb...
GSE121411: Acquired HER2 mutations in ER+ metastatic breast cancer confer resistance to ER-directed therapies
Estrogen receptor positive (ER+) breast cancers that develop resistance to therapies that target the...
GSE119270: Ptpn2 regulates the generation of cytotoxic Tim-3+ CD8+ T cells and restrains anti-tumor immunity
Cellular and transcriptional experiments demonstrate that deletion of Ptpn2 enhances CD8+ T cell res...
GSE119766: Single-cell RNA-seq of NR5A1-eGFP positive cells of the developing mouse ovary from E10.5 to P6
Purpose: We performed a time-course single-cell RNA-seq of the somatic cells of the XX mouse gonads ...
GSE114605: Silencing Xrn1 by dox-inducible shRNA
Xrn1 is a cytoplasmic 5-3 exoribonuclease responsible for degradation of multiple types of RNA. Data...
GSE114340: Commensal Microbiota Promote Lung Tumorigenesis via T Cells
Lung cancer is closely associated with chronic inflammation, but the mechanism underlying such infla...
GSE115354: Metabolic regulation of gene expression by histone lactylation
Cancer-augmented lactogenesis has been described by the Warburg effect, and is associated with sever...
GSE120882: The effects of H3.3K27M mutation on developing mouse brain and cooperation with Trp53 on enhancing tumorigenesis in the genetic model of H3.3K27M [RNA-Seq]
Diffuse intrinsic pontine gliomas (DIPG) are devastating pediatric brain tumors for which there is n...
GSE115905: Comparison of the response to the TNF treatment in C57BL6 and sst1 knockout TB resistant mouse macrophages
Macrophages derived from the wt and 1h mice were treated with the increasing concentrations of the T...
GSE121584: Steroid Receptor Coactivator-2 Regulated Transcriptome in Human Endometrial Stromal Cells
RNA-sequencing of mRNA isolated from in vitro decidualizaing human endometrial stromal cells with or...
GSE114453: Organoids derived from pancreatic adenocarcinoma patients share morphological and genetic features with the primary tumor [RNA-seq]
RNA sequencing demonstrates molecular profiles common to primary tumor, PDX and organoid models SOUR...
GSE114355: Gene expression profile of T cell after TCR stimulation with or without PD-1 engagement
Gene expression profile of T cell after TCR stimulation with or without PD-1 engagement was measured...
GSE116600: Oligodendrocyte precursor differentiation and survival requires chromatin remodeling by Chd7 and Chd8 [RNA-seq]
Oligodendrocyte precursor cells (OPCs) constitute the main proliferative cells in the adult brain, a...
GSE119779: SWI/SNF component ARID1A restrains pancreatic neoplasia formation [RNA-seq]
ARID1A restrains the formation of PanIN, pancreas ductal adenocarcinoma, and intraductal mucinous ne...
GSE117069: Integrated miRNA/mRNA-Seq of the Habenulo-Interpeduncular Withdrawal Circuit
Nicotine dependence is responsible for perpetuating the adverse health effects due to tobacco use, t...
GSE129583: Transcriptional control of lung alveolar type 1 cell development and maintenance by NK Homeobox 2-1 [RNA-Seq]
The extraordinarily thin alveolar type 1 (AT1) cell constitutes nearly the entire gas exchange surfa...
GSE121558: p53 Represses the Mevalonate Pathway to Mediate Tumor Suppression
We have discovered that loss of wild-type p53 correlates with elevated expression of mevalonate path...
GSE115919: KLF5 controls glutathione metabolism to suppress p190-BCR-ABL+ B-cell lymphoblastic leukemia
High-risk B-cell acute lymphoblastic leukemia (B-ALL) remains a therapeutic challenge despite advanc...
GSE107534: RNA-sequencing of cTECs, mTECs, and thymocyte maturation subsets SM, M1 and M2 from the CD4 and CD8 lineages from WT and Psmb11-deficient mice [DSP393]
Purpose: Cortical thymic epithelial cells (cTECs) contain a unique type of proteasomes, thymoproteas...
GSE121278: RNA-Seq of juvenile and early adolescent muscle
We report significant differences in muscle gene expression during postnatal development (4-8 weeks)...
GSE115311: CRISPR/Cas9-mediated Gene Knockout Reveals a Guardian Role of NF-kB/RelA in Maintaining the Homeostasis of Human Vascular Cells
Dysfunction of blood vessels leads to severe vasculature pathogenesis. Previous studies have demonst...
GSE106897: Loss of Lin28a Attenuates Cardiac Hypertrophy Induced by Pressure Overload
Pathological cardiac hypertrophy is a major risk factor for the development of heart failure and sud...
GSE114988: Single cell sequencing of BMP4 stimulated enteroendocrine cells in organoids
Enteroendocrine cells (EECs) alter hormone expression while migrating along the crypt-villus axis. W...