PLX276145

GSE85510: Major roles of cyclobutane pyrimidine dimers, nucleotide excision repair and ATR in the alternative splicing response to UV irradiation

  • Organsim human
  • Type RNASEQ
  • Target gene
  • Project ARCHS4

Alternative splicing (AS) is the main process that amplifies DNA information and is a crucial target of signaling cascades resulting from UV irradiation of human cells. The specific impact of UV-induced cyclobutane pyrimidine dimers (CPDs) at the transcriptional and AS levels has not been addressed. By using a CPD photolyase, a flavoenzyme that directly reverts CPDs, we analyze the contribution of this lesion to the expression program in human keratinocytes. SOURCE: Antonio Torres-MendezTranscriptomics of vertebrate development and evolution Centre for Genomic Regulation

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