PLX293707

GSE141924: Transcriptome analysis of brain endothelial cells from EC-specific Glut1 knock-out pups (P6) as compared to wild type controls

  • Organsim mouse
  • Type RNASEQ
  • Target gene
  • Project ARCHS4

To explore the mechanisms through which GLUT1 controls EC function, we compared transcriptomic alterations induced by loss of GLUT1 by performing RNA sequencing analysis on freshly isolated ECs from P6 GLUT1EC-/- brains. At P6, 447 genes were differentially expressed between WT and GLUT1-/- ECs. Subsequent gene set enrichment analysis showed that within the most differentially expressed pathways, several ones were related to p53, as well as inflammatory related pathways. SOURCE: Katrien De Bock (katrien-debock@ethz.ch) - Lab of Exercise and Health ETH Zurich

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