PLX270606

GSE136638: An Optimized Chemical-Genetic Method for Cell-Specific Metabolic Labeling of RNA

Organsim human
Type RNASEQ
Target gene
Project ARCHS4

We demonstrate that mammalian cells are able to salvage uracil analogs, yielding high background incorporation into cellular RNA. We also discover the enzymatic pathways responsible for this background. To overcome these limitations, we have developed a novel small-molecule/enzyme pair consisting of uridine/cytidine kinase 2 (UCK2) and 2'-azidouridine (2'AzUd). SOURCE: Whitney England (wengland@uci.edu) - University of California Irvine

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