PLX003660

GSE135413: Zika Virus Noncoding sfRNA Sequesters Multiple RNA Binding Proteins and Impacts mRNA Decay and Splicing

Organsim human
Type RNASEQ
Target gene
Project ARCHS4

Previous reports studying similar flavivirus infections (DENV, WNV, etc.) revealed an increase in both the abundance and stability of normally short-lived cellular mRNAs. This resulted from the stalling/repression of the major 5-3 host exoribonuclease XRN-1 on three-helix junction structures present in the 3-UTR of insect-borne flaviviruses. Therefore we sought to identify the endogenous mRNA abundance and stability changes induced during early and late times following Zika virus infection (PRBRAC59) in human choriocarcinoma (JAR) cells. SOURCE: Jeffrey Wilusz (jeffrey.wilusz@colostate.edu) - Colorado State University

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