PLX108915

GSE134779: Transcriptomic analysis of Tregs from RelB-dDC mice

  • Organsim mouse
  • Type RNASEQ
  • Target gene
  • Project ARCHS4

We report here the effect of RelB ablation in CD11c+ cells on the Treg compartment accross various organs.This mice have been backcrossed to a Foxp3 reporter mouse line to enable cell sorting of Tregs with a high purity. Interestingly, RelB ablation in DCs leads to a substantial accumulation of Tregs and these Tregs show a 'tissue Treg' signature including high expression levels of KLRG1, I1LRL1 and Gata3 when compared to Tregs of littermate control mice. SOURCE: Caspar Ohnamcht (caspar.ohnmacht@helmholtz-muenchen.de) - Mucosal Immunology Helmholtz Center Munich

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