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PLX320062
GSE98596: NMuMG cell response to TGF-beta and TGF-beta +2APB treatments
- Organsim mouse
- Type RNASEQ
- Target gene
- Project ARCHS4
Recent studies demonstrate that Ca2+ signaling has an important role in EMT. Use of Ca2+ blockers such as 2APB can inhibit cell migration induced by TGF-. Interestingly, we see an unexpected increase in Snail expression upon Ca2+ blocker treatment of both MCF10A and NMuMG cells; this increase is not observed with 2APB treatment alone. Therefore, we believe that 2APB plays a synergistic role with TGF- in Snail induction. We propose to investigate the gene networks that change following 2APB +TGF- treatment. SOURCE: Archana Dhasarathy (archana.dhasarathy@med.und.edu) - University of North Dakota
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