PLX312008

GSE94488: Harnessing BET inhibitor sensitivity reveals AMIGO2 as a melanoma survival gene.

• Organsim human
• Type RNASEQ
• Target gene
• Project ARCHS4

We utilize the transcriptional effects of BETi in melanoma and identify AMIGO2 as a direct target gene essential for melanoma cell survival both in vitro and in vivo. We further map the enhancer landscape of NHM and melanooma and show that genes regulated by super enhancers are expressed in higher levels, exihibit higher sensitivity to BETi, and over expressed in melanoma relative to NHM. In melanoma, AMIGO2 is regulated by super enhancers, which upon BETi lose their BRD2/BRD4 enrichment, resulting in AMIGO2 silencing. SOURCE: Emily Bernstein (emily.bernstein@mssm.edu) - Bernstein Lab Mount Sinai School of Medicine