PLX088091

GSE76947: A novel compound that blocks HIV-1 replication inhibits the splicing regulatory function of SRSF10

• Organsim human
• Type RNASEQ
• Target gene
• Project ARCHS4

Purpose: We have identified a new compound (1C8) that inhibits HIV-1 replication and that displays very low cellular toxicity. Here, we assess the molecular mechanisms of action of 1C8. Following transcription of the HIV-1 genome, its primary transcript is processed to produce dozens of distinct mRNAs through the alternative use of splice sites.; Results: 1C8 decreases the activity of SRSF10, a cellular protein that controls the selection of splice sites in HIV-1 transcripts. 1C8 decreases the phosphorylation of SRSF10, and this change is associated with alterations in the interaction of SRSF10 with HIV-1 transcripts and factors that control splice site selection. Thus, 1C8 represents a novel compound with properties that are potentially useful for treating HIV-1 infection. SOURCE: Benjamin,Andrew,Story (story.benjamin@gmail.com) - Stowers Institute for Medical Research