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PLX058805
GSE71679: Effect of Smyd1 conditional knockout on gene expression in skeletal muscle
- Organsim mouse
- Type RNASEQ
- Target gene
- Project ARCHS4
Transcriptome analysis by RNA-seq of tibialis anterior muscle from control and Smyd1 myocyte-specific conditional knockout mice at 6 weeks of age. Smyd1 is a methyltransferase specifically expressed in striated muscle and CD8+ T cells. Smyd1 deficiency resulted in centronuclear myopathy primarily affecting fast-twitch muscle fibers. These results provide insight into how loss of Smyd1 altered transcriptional programs resulting in centronuclear myopathy. SOURCE: M. David Stewart University of Houston
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