PLX311176

GSE156060: Influenza non-structural protein 1 (NS1) localization plays a key role in the anatagonism of host antiviral processes.

• Organsim human
• Type RNASEQ
• Target gene
• Project ARCHS4

The influenza virus is opportunistic by nature and is capable of subverting cellular signalling pathways for the benefit of viral replication. The function of non-structural protein 1 (NS1) as a core component for the influenza virus to interfere with host antiviral activity has been well cited in literature. However, the mechanism as to how NS1 is capble of subverting the host's innate immune system is unknown. NS1 has a unique capability to migrate between both the cytoplasm and nucleus of infected cells. To assess if NS1 interference operates a stratagy pertaining to a mechanism involved with nuclear-located signalling processes we designed two mutant virsus; WSNdelNS1 which encodes a deletion to prevent complete NS1 expression and WSN3M which encodes a NS1-variant that is defective in NS1 nuclear-translocation, thus preventing NS1 from entering the nuclus of infected cells. SOURCE: Honglin Chen (hlchen@hku.hk) - State Key Laboratory for Emerging Infectious Diseases, Li Ka Shing Faculty of Medicine The University of Hong Kong