PLX310907

GSE155918: Primate innate immune responses to bacterial and viral pathogens reveals an evolutionary trade-off between strength and specificity

• Organsim human
• Type RNASEQ
• Target gene
• Project ARCHS4

We report the whole genome transcriptomic responses of ape species (human, common chimpanzee) and AAMs (rhesus macaque and olive baboon) to bacterial and viral stimulation. We find stark differences in the responsiveness of these groups, with apes mounting a markedly stronger early transcriptional response to both viral and bacterial stimulation, altering the transcription of 40% more genes than AAMs. Additionally, we find that genes involved in the regulation of inflammatory and interferon responses show the most divergent early transcriptional responses across primates and that this divergence is attenuated over time. Finally, we find that relative to AAMs, apes engage a much less specific immune response to different classes of pathogens during the early hours of infection, upregulating genes typical of anti-viral and anti-bacterial responses regardless of the nature of the stimulus SOURCE: Luis,B,Barreiro (lbarreiro@uchicago.edu) - Barreiro Lab Chicago University