PLX263415

GSE155359: Charaterization of function of ST2 receptor on macrophages function during Club cell regeneration after naphthalene injury in WT mice

• Organsim mouse
• Type RNASEQ
• Target gene
• Project ARCHS4

During repair phase after naphathalene injury 3 subsets of myeloid cells accumulate at the site of injury including P1 (monoyte), P2 (monocyte-derived macrophages and P3 (resident alternatively activated airway macrophages). ST2 receptor was found to be expressed by P2 and P3 subsets. To understand which biological processes in lung macrophages were regulated by ST2, myeloid cell subsets were flow-sorted from Naphthalene-treated WT and ST2-/- mice on d6 and their transcriptome analyzed using RNA-seq SOURCE: Jingya Wang (jingya.wang@astrazeneca.com) - Astrazeneca