PLX309933

GSE153806: Differentially expressed genes during pancreatic progenitor cell differentiation and proliferation

Organsim human
Type RNASEQ
Target gene
Project ARCHS4

A small molecule, AT7867, is a proliferation-promoting factor of human iPS cell-derived pancreatic progenitor cells; yet how it promotes cell proliferation is not known. AT7867 induces proliferation of pancreatic progenitor cells, but not that of definitive endoderm cells or primitive gut tube cells suggesting a cell type-specific effect. Our aim is to perform RNA-seq of cells obtained during a three stage differentiation of hiPS cells to the endodermal cell lineage in addition to pancreatic progenitor cells treated with AT7867, and analyze signaling pathways altered by the compound treatment. SOURCE: Kenji Osafune Kyoto University

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