PLX078499

GSE149508: Gene Expression Patterns of Quiescent and Activated Mouse Primary Hepatic Stellate Cell (HSC)

• Organsim mouse
• Type RNASEQ
• Target gene
• Project ARCHS4

Liver fibrosis is a manifestation of chronic liver injury. It leads to hepatic dysfunction and is a critical element in the pathogenesis of cirrhosis and hepatocellular carcinoma. The activation of hepatic stellate cells (HSC) plays a central role in liver fibrogenesis of different etiologies. To elucidate the molecular mechanism of this phenomenon, it is important to analyze the changes in gene expression that accompany the HSC activation process. In this study, we isolated quiescent and activated HSCs from control mice and mice with CCl4-induced liver fibrosis, respectively, and performed RNA sequencing to compare the differences in gene expression patterns between the two types of HSCs. SOURCE: Chen Qu (cheyne1988@outlook.com) - Jinan University