PLX046954

GSE146900: Quantitative Analysis of Wild Type and CTGF-/- Retinal Transcriptomes During Postnatal Vascular Development

• Organsim mouse
• Type RNASEQ
• Target gene
• Project ARCHS4

Purpose: The goal of this study is to compare the retinal transcriptomes of wild-type and CTGF-/- mice during postnatal development of the retinal vasculature.; Results: The results from principal component analysis (PCA) showed a distinguishable gene expression profiling among the samples. The expression level (FPKM value) of known genes and transcripts were calculated using ballgown through the transcript abundances estimated with StringTie. The number of identified genes and transcripts per group was calculated based on the mean of FPKM in group > 0.5. We have identified 24,818 transcripts for 12946 gene count in WT mouse retinas and 24708 transcripts for 12852 gene count in knockout mouse retinas. The significantly enriched GO terms of the differentially expressed genes include those involved in protein, lipid and DNA metabolism, neurogenesis and signal transduction and gene regulation. SOURCE: Brahim Chaqour (brahim.chaqour@downstate.edu) - SUNY Downstate Medical Center