PLX278325

GSE146643: Transcriptome of CD4+ T cells from mice conditionally lacking YAP1 versus WT in different synthetic micromechanical environments

• Organsim mouse
• Type RNASEQ
• Target gene
• Project ARCHS4

Upon immunogenic challenge, lymph nodes become mechanically stiff as immune cells activate and proliferate within their encapsulated environments, and with resolution, they reestablish a soft, baseline state. Here we show that sensing these mechanical changes in the microenvironment require the mechanosensor YAP. YAP is induced upon activation and suppresses metabolic reprogramming of effector T cells. Unlike in other cell types where YAP promotes proliferation, YAP in T cells suppresses proliferation in a stiffness-dependent manner by directly restricting the translocation of NFAT1 into the nucleus. YAP slows T-cell responses in systemic viral infections and retards effector T cells in autoimmune diabetes. Our work reveals a paradigm whereby tissue mechanics fine-tune adaptive immune responses in health and disease. SOURCE: Manish,J,Butte (mbutte@mednet.ucla.edu) - UCLA