PLX066800

GSE130888: Single cell transcriptome of peritoneal cells

• Organsim human
• Type RNASEQ
• Target gene
• Project ARCHS4

To define the transcriptomic landscape of human mesothelial cells in response to PD, we analyzed single cell transcriptomes including cells dissociated from normal peritoneum (hernia surgery, n = 3), and peritoneal cells from effluent of short-term PD patients (PD less than 2 weeks, n = 6) and from long-term PD patients (PD more than 6 years, n = 4) ,we demonstrate that mesothelial cells develop hyperglycolysis, a metabolic alteration that is correlated with the development of peritoneal fibrosis. SOURCE: Meijun Si (simeijunsysu@163.com) - The 3rd Affiliated Hospital of Sun Yat-sen University