PLX262681

GSE123976: DNA Methylation Reprograms Metabolic Gene Expression in End-Stage Human Heart Failure

• Organsim human
• Type RNASEQ
• Target gene
• Project ARCHS4

Heart Failure (HF) is a complex clinical disease and leading cause of hospitalization in the United States. Although precision-based treatment options are ultimately preferred, understanding the common underlying features of HF is also needed to develop universal therapies that address its pathogenesis. Among the etiology-independent molecular changes known to occur in HF is a global shift in the hearts metabolic substrate preference. Transcriptional reprogramming of the heart has been shown to mediate this metabolic switch towards glycolytic metabolism; however, the molecular machinery that reactivate dormant genes remain largely unknown. In the current study, we hypothesized that the cardiac epigenome regulates metabolism via alterations in DNA methylation. SOURCE: Mark,Emile,Pepin (pepinme@uab.edu) - Adam Wende Laboratory University of Alabama at Birmingham