PLX166369

GSE119707: C/EBP regulates the M2 transcriptome in -adrenergic-stimulated macrophages

  • Organsim mouse
  • Type RNASEQ
  • Target gene
  • Project ARCHS4

We screened RNAseq results from RAW 264.7 macrophages for previous empirically-defined M2 genes in the whole transcriptome that followed the Arg1 pattern of up-regulation by -adrenergic-signaling with inhibition by Cebpb gene knockdown. We also screened RAW 264.7 macrophages for empirically-defined M1 genes that exhibited the orthogonal pattern of Arg1 regulation (i.e., down-regulation by -adrenergic signaling, with rescue of this effect by Cebpb knockdown). SOURCE: Donald,M.,Lamkin (dlamkin@ucla.edu) - UCLA

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