PLX236766

GSE118246: RNA sequencing of genetically engineered mouse model lung tumors and normal mouse lung.

  • Organsim mouse
  • Type RNASEQ
  • Target gene
  • Project ARCHS4

Genetically engineered mouse models (GEMM) of cancer are powerful tools to study multiple aspects of caner biology. We developed a novel GEMM for lung squamous cell carcinoma (LSCC) by genetically combining overexpression of Sox2 with loss of Lkb1: Rosa26LSL-Sox2-IRES-GFP;Lkb1fl/fl (SL). We compared gene expression profiles of SL lung tumors with normal mouse lung tissue, mouse lung adenocarcinoma (LADC) tumors from KrasLSL-G12D/+;Trp53fl/fl (KP), mouse LSCC tumors from Lkb1fl/fl;Ptenfl/fl (LP) model as well as Lenti-Sox2-Cre Lkb1fl/fl. SOURCE: Trudy Oliver (Trudy.Oliver@hci.utah.edu) - Oliver University of Utah

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