PLX139550

GSE107620: Global hypomethylation mediated changes regulate constitutive PD-L1 expression in melanoma [RNA-Seq]

• Organsim human
• Type RNASEQ
• Target gene
• Project ARCHS4

PD-L1 is a ligand for the inhibitory PD1 receptor on T cells and its expression in some cancers inhibits anti-cancer immune response. In melanoma, PD-L1 expression is induced in response to immune stimuli but in a proportion of melanomas it is constitutively expressed. Factors that drive constitutive expression of PD-L1 are unknown. Here we performed RNA-Seq analysis of six cell lines that constitutively express PD-L1 (PD-L1 positive, referred to as PD-L1CON) and six cell lines that only express PD-L1 after treatment with IFN- (PD-L1 negative, referred to as PD-L1IND) SOURCE: Aniruddha Chatterjee (aniruddha.chatterjee@otago.ac.nz) - Epigenetics and Disease University of Otago