PLX211935

GSE106920: Epigenetic Reprogramming of Tissue-Specific Transcription Promotes Colorectal Cancer Metastasis to Liver (RNA-Seq)

• Organsim human
• Type RNASEQ
• Target gene
• Project ARCHS4

Metastasis is the cause of death for 90% of cancer patients, but little is known about how cancer cells adapt to and colonize new tissue environments. Using clinical samples and primary/metastatic cell lines, we found metastatic colorectal cancer (CRC) cells lose their colon-specific gene transcription program and gain a liver-specific gene transcription program as they metastasize in the liver. We revealed this transcription reprogramming is driven by a reshaped epigenetic landscape of both typical and super-enhancers. Further, we identified FOXA2, a liver-specific transcription factor, plays a key role in this transcription reprogramming and the colonization of metastatic CRC cells in the liver. Notably, this transcription reprogramming is also observed in multiple cancer types. Our data demonstrate that epigenetically reprogrammed tissue-specific transcription promotes metastasis and should be targeted therapeutically. SOURCE: Yang,Eric,Li (liyang01133@gmail.com) - Zhi John Lu Tsinghua University