PLX291422

GSE106290: Induced MIST1 and PTF1a Expression in Pancreatic Ductal Adenocarcinoma Cells

• Organsim human
• Type RNASEQ
• Target gene
• Project ARCHS4

Purpose: The goal of the study was to determine the effects of forced expression of the acinar transcription factors MIST1 and PTF1a in PDAC cells.; Methods: Doxycycline inducible MIST1myc and PTF1amyc Panc-1 cells were generated using Clontech's Tetone System and subjected to RNA-Sequencing following doxycycline treatment.; Results: 50 million sequence reads were mapped to the human genome. Data suggests acinar associated molecules were induced upon doxycyline treatment.; Conclusions: MIST1 and PTF1a retain functional activity and can promote acinar gene expression in the context of pancreatic cancer cells. SOURCE: Brad,LaMar,Jakubison (Bjakubis@purdue.edu) - Stephen Konieczny Purdue University