PLX099955

GSE102639: RNA seq_A375 gSMARCB1 + A549 etoposide, Aurora kinases inhibitors treated

  • Organsim human
  • Type RNASEQ
  • Target gene
  • Project ARCHS4

To study the senescence gene signatures in the cells, which were genetic SMARCB1 depleted or treated with aurora kinase inhibitors or etoposide, we performed next generation RNA sequencing on these cell, and 'FRIDMAN_SENESCENCE_UP' geneset was used to determine the enrichment of senescence-related genes. The RNA sequencing results include (1) A375 cells and SMARCB1 depleted counterparts. (2) A549 cells and aurora kinase inhibitor (Alisertib, barasertib or tozasertib) or etoposide treated counterparts. SOURCE: Liqin Wang (l.wang@nki.nl) - Bernards NKI-AVL

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