PLX051831

GSE57397: Transriptional profiling upon heat shock and recovery in cells deficient for FBXW7 and their wild type counterpart.

• Organsim human
• Type RNASEQ
• Target gene
• Project ARCHS4

FBXW7 modulates stress response by post-translational modification of HSF1; HSF1 orchestrates the heat-shock response upon exposure to heat stress and activates a transcriptional program vital for cancer cells. Genes positively regulated by HSF1 show increeased expression during heat shock while their expression is reduced during recovery. Genes negatively regulated by HSF1 show the opposite pattern. In this study we utilized the HCT116 FBXW7 KO colon cell line and its wild type counterpart to monitor gene expression changes during heat shock (42oC, 1 hour) and recovery (37oC for 2 hours post heat shock) using RNA sequencing. These results revealed that the heat-shock response pathway is prolonged in cells deficient for FBXW7. SOURCE: Nikos Kourtis (nkourtis@gmail.com) - NYU School of Medicine