We have analyzed changes in histone 3 lysine 4 methylation (H3K4me) and gene expression resulting either from Kmt2a or Kmt2b knockdown in adult hippocampal CA neurons in mice. We implemented Cre/loxP-mediated conditional knockout strategy in order to knockdown either of these histone methyltransferases in excitatory forebrain neurons in adult mice. SOURCE: Gaurav Jain (gauravj49@gmail.com) -  The German Center for Neurodegenerative Diseases (German: Deutsches Zentrum für Neurodegenerative Erkrankungen DZNE)

Pluto Bioinformatics

GSE99250: Kmt2a and Kmt2b Control Memory Function via Different Transcriptional Programs