Pluto Bioinformatics

GSE156487: IER5 is required for Notch-mediated induction of squamous cell differentiation [RNA-seq]

Bulk RNA sequencing

Conditional activation of Notch in squamous cells activates a context-specific gene expression program through lineage-specific regulatory elements. IER5 is a direct Notch-regulated gene and required for Notch-induced differentiation of squamous carcinoma cells. SOURCE: Li PanJon Aster Brigham and Women's Hospital