Pluto Bioinformatics

GSE156221: Anti-cancer activity of Cotyledon orbiculata extract

Bulk RNA sequencing

We investigated the effects of the crude extract of a South African medicinal plant, Cotyledon orbiculata, on cell survival of colon (HCT116) cancer cell lines. Using RNASeq, we discovered that the extract interfered with mRNA regulatory pathways. Here, we found that the extract of Cotyledon orbiculata, a South African medicinal plant, had an anti-proliferative effect in cancer cells, mediated by apoptosis induced by alternative splicing of hnRNPA2B1 and BCL2L1. SOURCE: Nigel,P,Mongan University of Nottingham

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