Pluto Bioinformatics

GSE106602: Expression profile of early and mid-secretory human endometrium revealed by RNA-seq: a paired-sample cohort study

Bulk RNA sequencing

Inner uterine lining or endometrium is a unique constantly self-renewed adult tissue that is vital for embryo implantation. As the footrace for universal endometrial receptivity markers continues, RNA-seq remains the most powerful tool for transcriptomic marker discovery. In this study, we aimed to elucidate endometrial maturation mechanisms at transcriptomic level and identify novel robust biomarker candidates for endometrial receptivity in a multicentre study. Additionally, we compared mid-secretory transcriptome profiles from healthy women with profiles of women with repeated IVF failure to find transcriptome changes related to problems with endometrial receptivity. SOURCE: Viktorija Kukushkina Estonian Genome Center, University of Tartu

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