Pluto Bioinformatics

GSE155941: Transcriptional profiling of senescent A549 cells

Bulk RNA sequencing

Telomere dysfunction is the most common identifiable cause of pulmonary fibrosis. Cellular senescence of epithlial cells is thought to play a signfiicant role in disease pathogensis. We established a model of cellular senescence using a human alveolar epithelilial-like cell lines (A549) and profiled the transcriptional changes that occur in response to telomere dyfunction. Telomere dysfunction was induced by expressing a dominant-negative form TRF2, the shelterin binding protein. SOURCE: Jonathan,K.,Alder (jalder@pitt.edu) - Alder Lab University of Pittsburgh