Pluto Bioinformatics

GSE155941: Transcriptional profiling of senescent A549 cells

Bulk RNA sequencing

Telomere dysfunction is the most common identifiable cause of pulmonary fibrosis. Cellular senescence of epithlial cells is thought to play a signfiicant role in disease pathogensis. We established a model of cellular senescence using a human alveolar epithelilial-like cell lines (A549) and profiled the transcriptional changes that occur in response to telomere dyfunction. Telomere dysfunction was induced by expressing a dominant-negative form TRF2, the shelterin binding protein. SOURCE: Jonathan,K.,Alder ( - Alder Lab University of Pittsburgh

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