Pluto Bioinformatics

GSE106601: tRNA modification landscape selectively controls mitochondrial translation efficiency in MERRF

Bulk RNA sequencing

We identified a novel N1-methyladenosine (m1A) modification in tRNALys with distinct effects on the synthesis and stabilities of the 13 mitochondrial proteins. Moreover, we observed regulated RNA modifications of mitochondrial tRNAs for the control of mitochondrial gene expression. Collectively, our data provide unprecedented insight into the regulation of mitochondrial tRNAs and reveal greater complexity to the molecular pathogenesis of MERRF. SOURCE: Tao Pan (taopan@uchicago.edu) - University of Chicago