We found that the transcriptinal co-activator TAZ is a basal cell marker for the prostate epithelium which is lost in the prostate cancer tissues and re-expression of TAZ in the prostate cancers may be a indicator of malignancy. TAZ promotes cell migraiton, EMT and metastasis in the prostate cancers. To elucidate the underlying mechanism, we performed the RNA-seq analysis of TAZ knockdown DU145 cells using two independent TAZ shRNA and pLKO control cells. SOURCE: Chen-Ying Liu (cyliu_eric@126.com) -  Xinhua Hospital, Shanghai Jiao Tong University

Pluto Bioinformatics

GSE93748: Identification of target genes of TAZ in the prostate cancer cells