Pluto Bioinformatics

GSE98496: mRNA-seq data from murine colon adenomas and non-adenoma tissues

Bulk RNA sequencing

We report that colon adenomas from ApcMin/+ mice not only exhibit similarities in gene expression profile to colon adenomas from azoxymethane / dextran sulfate sodium-treated mice (with activating Ctnnb1 mutations) due to the activation of canonical WNT signaling, but also unique transcriptional changes in the pathways regulating cell cycle progression / proliferation, chromosome segregation / cytoskeletal organization and apoptosis. Subsequent experiments characterized changes in gene expression unique to colon adenomas from ApcMin/+ mice including increases in the H2afv, Map6 and Nsmf transcripts. SOURCE: Joanna Groden (groden.2@osu.edu) - The Ohio State University, College of Medicine