Pluto Bioinformatics

GSE150481: Resilience and susceptibility in a mouse model of immune-mediated neurodevelopmental disorders

Bulk RNA sequencing

We identify and characterize subgroups of isogenic mouse offspring exposed to identical maternal immune activation induced by gestational administration of the viral mimetic, poly(I:C). We demonstrate that offspring with manifest impairments in social behavior, sensorimotor gating and working memory (susceptible offspring) differ from asymptomatic (resilient offspring) in terms of their transcriptional profiles in cortical and subcortical brain regions, while displaying only subtle differences in brain morphometry SOURCE: giancarlo russo ( - ETH/University of Zurich

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