Pluto Bioinformatics

GSE144903: Genome-wide investigation of the dynamic changes of epigenome modifications after DNA methylation editing [RNA-seq]

Bulk RNA sequencing

The aim of this study was to investigate the stability of DNA methylation, the dynamics of different histone modifications and the changes in expression after genome-wide introduction of DNA methylation in promotor CpG islands. Therefore, the catalytic domain of DNMT3A was fused to a zinc finger protein and expressed for three days to globally introduce de novo DNA methylation and subsequently, the changes in the epigenome were monitored for up to eleven days. SOURCE: Albert Jeltsch ( - University Stuttgart

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