Pluto Bioinformatics

GSE93226: Transcriptomic profiles of human foreskin fibroblast cells in response to orf virus

Bulk RNA sequencing

Using RNA sequencing technology, we compared specic changes in the transcriptomic proles in human foreskin fibroblast cells (HFF-1) following ORFV infection. ORFV specically upregulated and downregulated a variety of genes, including genes involved in antiviral immune response, apoptosis, cell cycle and a series of signaling pathways, such as the IFN and p53-signaling pathways. A range of genes were downregulated at early stage. In contrast, the virus up-regulates a number of cellular genes at late stage. SOURCE: Daxiang Chen Southern Medical University