Pluto Bioinformatics

GSE142151: Chromatin states and transcriptome of CD8+ T cells over the course of differentiation

Bulk RNA sequencing

The goal of this study is to analyze the contribution of transposable elements (TEs) tocis-regulation in CD8+ T cells. Using a combination of NGS techniques we show that specific subfamilies of TEs are enriched, and distributed in a lineage-specific fashion in core and boundary domains of CD8+T cell enhancers.This study represents the first detailed analysis of the topology and the enhancer domain-associated putative functions of distinct TE types. SOURCE: Mengliang YE ( - Institut Curie

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