Pluto Bioinformatics

GSE142072: Cripto shapes macrophage plasticity and restricts EndMT in injured and diseased skeletal muscle

Bulk RNA sequencing

The membrane protein Cripto plays a key role in shaping macrophage plasticity in skeletal muscle during regeneration and disease. Cripto acts as an extrinsic modulator of macrophage plasticity and is required for the proper expansion/maintenance of the CD206+ anti-inflammatory macrophage population. Nevertheless, Cripto deletion does not change the gene expression profile of F4/80+/Ly6CLow macrophages suggesting that Cripto was dispensable to induce/maintain the Ly6CLow phenotype. SOURCE: Eusebio Perdiguero (eusebio.perdiguero@upf.edu) - Cell Biology UPF