Pluto Bioinformatics

GSE140230: Tacrolimus- and sirolimus-induced human b cell dysfunction is reversible and preventable

Bulk RNA sequencing

We used RNA-seq to investigate transcriptional changes in human islet grafts that were treated in vivo with tacrolimus or sirolimus. We show that this treatment induces broad transcriptional dysregulation related to peptide processing, ion/calcium flux, and the extracellular matrix. SOURCE: Alvin,C,Powers (Al.Powers@vanderbilt.edu) - Vanderbilt University