Pluto Bioinformatics

GSE90497: Steatohepatitis progresses to cancer via immunosuppression of HCC directed CD8+ T cells

Bulk RNA sequencing

We show that chronic inflammation and fibrosis in mice with non-alcoholic fatty liver disease (NASH) is accompanied by accumulation of immunoglobulin A (IgA) positive plasmocytes. These cells suppress activation of cytotoxic T cells (CTL) derived from liver infiltrating CD8+ cells. CD8+ T cell ablation greatly accelerates HCC appearance, genetic or pharmacological targeting of IgA and PD-L1 expressing plasmocytes attenuates hepatic carcinogenesis and induces CTL-dependent regression of established HCC. SOURCE: Max Chang (mchang@ucsd.edu) - University of California, San Diego