Pluto Bioinformatics

GSE142019: Effect of Ythdf2 in haematopoiesis [RNA-seq]

Bulk RNA sequencing

The mRNA m6A reader YTHDF2 is overexpressed in human acute myeloid leukaemias. To understand the role of YTHDF2 in normal haematopoiesis and ageing, we performed SMART-seq on haematopoietic stem cells (HSCs) derived from young and aged (1 year old) mice. In parallel, to identify transcripts likely methylated in HSCs we performed meRIP-seq analysis of c-Kit+ cells. SOURCE: Donal O'Carroll University of Edinburgh