Pluto Bioinformatics

GSE132140: TGF signaling in retinal tissue repair [Mus Musculus]

Bulk RNA sequencing

In mammals, retinal damage is followed by Mller glia cell activation and proliferation. While retinal gliosis persists in adult mammals after an insult or disease, some vertebrates, including zebrafish, have the capacity to regenerate. We believe we are the first group to show that gliosis is a fibrotic-like process in mammals eyes caused by differential activation of canonical and non-canonical TGF signaling pathways. SOURCE: Federica Maria Conedera (federica.conedera@insel.ch) - Inselspital-University of Bern