Pluto Bioinformatics

GSE134439: Mapping Gata2 enhancer-dependent developmental trajectories by single-cell RNA-sequencing

Bulk RNA sequencing

We compared single-cell transcriptomes of fetal liver myeloid progenitor pools (CMP/GMP pool) from Gata2 -77 enhancer mutant embryos and wildtype littermates. Gene expression patterns in -77-deficient mice demonstrated loss of erythroid, megakaryocyte and granulocyte progenitors and an increase in monocyte SOURCE: Emery Bresnick (dconn2@wisc.edu) - Bresnick Lab University of Wisconsin-Madison