The Sanaria PfSPZ Vaccine can confer sterilizing protection against liver stage infection by Plasmodium falciparum (Pf) in malaria nave individuals. The vaccine consists of aseptically purified irradiated Pf sporozoites. The PfSPZ Vaccine trial in Mali was the first to evaluate the safety and efficacy of this vaccine in a malaria endemic region. Vaccinees received five doses of 2.7 X 105 irradiated sporozoites and the efficacy was measured against naturally occurring Pf Infections in Malian adults during the malaria transmission season. SOURCE: Robert,D,Morrison (bob.morrison@cidresearch.org) -  Center for Infectious Disease Research

Pluto Bioinformatics

GSE86308: Transcription profiling of PfSPZ Malaria Vaccine trial subjects in a malaria endemic region