Pluto Bioinformatics

GSE100990: NR4A1 and NR4A3 Restrict HSC Proliferation via Reciprocal Regulation of C/EBP and Inflammatory Signaling

Bulk RNA sequencing

NR4A nuclear receptors are known tumor suppressors of acute myeloid leukemia and are essential regulators of hematopoietic stem cell (HSC) quiescence. To study the transcriptional consequences of acute NR4A1/3 codepletion in HSCs, we used an Nr4a1/3 conditional knockout mouse model and performed a global transcriptome profiling using RNA-Seq in sorted HSCs four days after NR4A1/3 codepletion. SOURCE: Pablo,Riera,Freire (freire@bcm.edu) - Baylor College of Medicine