We observed different gene expression by overexpressing the transcription factor FOXP2 in U2OS cells compared to mock-transfected cells. Additionally, we found -catenin as co-activator binding directly to FOXP2. Activation of Wnt signaling was changing the transcriptional activity of FOXP2. Other functional and regulatory elements were found within FOXP2 and were confirmed by RNA-Seq. SOURCE: Gesa Richter (gesa.richter@medunigraz.at) -  Medical University Graz

Pluto Bioinformatics

GSE138938: -catenin regulates FOXP2 transcriptional activity via multiple binding sites