Pluto Bioinformatics

GSE129384: Analysis of gene expression in colonic epithelial cells following DSS treatment

Bulk RNA sequencing

Mice with and without IFNAR expression were treated with broad-spectrum antibiotics for more than 10 days, either infected with MNV or left uninfected and then treated with 3% DSS in drinking water for 6 days. Intestinal epithelial cells were isolated from the colon and sorted and RNA extracted for RNASeq analysis. We found that mice with IFNAR expression on IEC and infected with MNV had a gene expression signature of DNA repair similar that induced by IL-22 signaling. SOURCE: Jessica Neil (Jessica.Neil@nyulangone.org) - Skirball Institute, NYU School of Medicine