Pregnancy is a time of extreme metabolic demand that requires coordinated adaptations between mother and fetus. To determine the contributions of maternal and fetal metabolism to metabolic plasticity during gestation, mice with a liver-specific Carnitine Palmitoyltransferase-2 knockout mice (Cpt2-/-), or Ppar KO mice were subjected to late-gestation nutrient stress, a 24hr fast from E16.5 to E17.5. The fetal response to maternal fasting was dominated by maternal lipid metabolism as the loss of maternal hepatic fatty acid oxidation or Ppar signaling accelerated fetal liver transcriptional programing. These data show that maternal nutritional environment is a major driver of perinatal metabolic programing and plasticity. SOURCE: Michael,J.,Wolfgang (mwolfga1@jhmi.edu) - Rangos Bldg 475 The Johns Hopkins University School of Medicine

Pluto Bioinformatics

GSE129368: Regulation of fetal liver transcription by maternal nutritional stress