Pluto Bioinformatics

GSE85532: RNASeq comparing Thpok and LRF-deficient Tregs to Control

Bulk RNA sequencing

The transcription factor Thpok is required for intrathymic CD4+ T cell differentiation and, together with its homolog LRF, supports CD4+ T cell helper effector responses, However, it is not known if these factors are needed for the T regulatory arm of MHC-II responses. We inactivated the genes encoding both factors in differentiated Treg cells, to see whether how they are redundantly required to maintain the size and function of the post-thymic Treg pool and for immune homeostasis. SOURCE: Margaret,C,Cam (maggie.cam@nih.gov) - NIH